HPV Vaccine

by | Sujit Rathod -


"The study, published in the New England Journal of Medicine, showed that of nearly 1.7 million girls and women, those who had been vaccinated before the age of 17 had their risk of developing cervical cancer reduced by 88%, while the risk for those vaccinated between the ages of 17 and 30 dropped by 53%."

1. What are the relative risk figures which led the journalist to report reductions by 88% and 53%?

2. There's an important epidemiologic detail missing from the statement above. What is it? (Apologies for being vague!)

3. Comment on the choice of outcome (endpoint). How is this an improvement over previous studies? Can you propose something even better?

Maternal health for Black women

by | Sujit Rathod -

1. "In the UK, Black women are five times more likely to die in pregnancy or childbirth than white women."

How did the investigators calculate this number? What is the epi label you would use for this number?

2. "Black women are more likely to have conditions that can put them at greater risk, including cardiac disease, diabetes and high blood pressure,"

What epidemiologic concept is implied here? Explain why the investigators decided to consider these measures.

3. "...when Black and Asian women do not have pre-existing medical conditions, have English as their first language and come from middle-class backgrounds, they still have worse outcomes compared with white women from a similar background.."

Why did the investigators do this comparison, as opposed to a comparison with the wider population of Black, Asian and white women?


Foetal alcohol disorder

by | Sujit Rathod -

From The Guardian.

1. What study design did the charity use?

2. How might their findings be affected by sampling bias?

3. "Among the adopters surveyed by the charity Adoption UK, 8% of children had a diagnosis, and a further 17% were suspected by their parents to have foetal alcohol spectrum disorder (FASD)".

Comment on the case definitions. What are in the numerators and denominators for these calculations? How might the findings be affected by measurement bias?

4. Dr Luisa Zuccolo says "There is far too much uncertainty on the actual extent of this problem.."

How would you design a study to reduce the uncertainty?

5. "Nice [National Institute for Health and Care Excellence]  says there is no known safe level of alcohol consumption during pregnancy."

How would you establish a safe level of consumption?

Accessibility

Background Colour

Font Face

Font Size

1

Text Colour