Hi Lena and Sujit,
1. What is the study design?
cohort study
2. What are the exposure / comparison groups? Who is used as the reference group?
children put in top, middle and bottom sets, both between and within classes, with the reference group being children in a mixed ability class
3. What are the outcomes?
peer, emotional, hyperactivity and conduct problems at 7, 11 and 14 years of age
4. What mediators have been proposed?
learning dynamics, peer processes, and subtle effects of in-class ability grouping (thanks to Lena for this)
5. The article makes no reference to confounders. Can you suggest one important confounder, and explain why?
The most obvious confounder would be the school. As the school will be associated both with the exposure (setting) and the outcome (behaviour problems) and is not on the causal pathway between them.
If some schools have more children with behavioural difficulties than others, then they may be more prone to put children into sets than schools where most children are well behaved.
If some schools have year groups with greater ranges of academic ability than others then they may be more prone to put children into sets than schools where most children are of similar ability. It may be more distressing for lower ability children in these schools to observe that they are struggling academically when compared to their peers, and this distress may manifest as behavioural problems.
6. Could this research question be investigated with a case-control design?
It could, but this would not overcome the possibility of reverse causation. I also agree with Lena that it would be difficult to match cases and controls.
7. Do we need a trial to demonstrate the association is causal? Can you think of one advantage and one disadvantage of doing a trial?
An advantage is that a large RCT would be a possible way to investigate causality.
A disadvantage is that it is unlikely that teachers or parents would feel the equipoise needed to run a trial. It also could not be blinded to teachers or students. Researchers assessing behavioural outcomes could be blinded when assessing children, but often they rely on the reports of teachers, students and parents who could not be blinded.
8. Additional points
It seems possible that behavioural problems cause poor academic ability, but this would be reverse causation rather than confounding.
We are not told whether there is a higher proportion of children with behavioural difficulties in the schools with sets or not. If not, then it may be that the sets are organising children by quality of behaviour as well as academic ability. Even if there is a higher proportion of children with behavioural difficulties in schools with sets this may be a confounder as mentioned previously.
Thank you also for letting us know about Zena Stein. What a very likeable and impressive woman. I'm not able to access NY Times articles without paying, but I found a free obituary here
https://www.publichealth.columbia.edu/public-health-now/news/memory-zena-stein-public-health-pioneer-advocate-justice
Best wishes
Judith